Searchable abstracts of presentations at key conferences in oncology

oa0001p018 | (1) | PacRim7

Assessing alterations in organelle contacts during prostate cancer development

Evergren Emma , Butler Lisa

Aggressive prostate cancer is characterized by altered lipid metabolism and metabolic stress. At a subcellular level these changes are localized to the endoplasmic reticulum (ER) and mitochondria. Traditionally the function of these organelles has been studied separately. A growing body of evidence shows that the interaction between mitochondria and ER at specialized membrane contact sites play a key role in regulating fundamental cellular processes such as lipid synthesis, mi...

oa0001p036 | (1) | PacRim7

Lipid elongation in prostate cancer: an androgen regulated process and a novel therapeutic target

Nassar Zeyad D , Centenera Margaret M , Machiels Jelle , Zinonos Irene , Hanson Adrienne , Bloch Katarzyna , Mah Chui Yan , Ryan Natalie K , Williams Elizabeth D , Evdokiou Andreas , Tilley Wayne D , Selth Luke A , Butler Lisa M , Swinnen Johannes V

Objective: Although initially effective, androgen deprivation therapy fails to achieve an enduring remission in patients with advanced prostate cancer (PCa) and the cells maintain active androgen receptor (AR) signalling. Hence, a detailed understanding of the AR-driven downstream processes that are required for tumour cell growth and survival, such as lipid metabolism, is essential to reveal new therapeutic targets. In this study, we aimed to evaluate the effect of androgens ...