Searchable abstracts of presentations at key conferences in oncology

oa0001p011 | (1) | PacRim7

The WinPro study: A window of opportunity study of endocrine therapy with and without prometrium in postmenopausal women with early stage hormone receptor-positive breast cancer

Chen Julia , Carson Emma , Segara Davendra , Parker Andrew , O'Toole Sandra , Coates Alan , Mann Bruce , Lindeman Geoffrey , Tilley Wayne , Lim Elgene

There is bidirectional interplay between PR and ER in human breast cancers. There is evidence for a reprogramming of ER chromatin binding sites with 470 genes differentially regulated by dual treatment with estrogen plus progestogen compared to estrogen alone in breast cancer cell lines. Functionally, there was an additive anti-cancer effect with the addition of natural progesterone to endocrine therapy in preclinical breast cancer models. This is a phase II multi-site, random...