Searchable abstracts of presentations at key conferences in oncology

oa0001p040 | (1) | PacRim7

Unravelling the role of cell plasticity in BrCa development and metastasis

Juan Beatriz Perez San , Zadeh Soroor , Ganju Vinod , Vargas Cristina , O'Toole Sandra , Lim Elgene , Davis Melissa , Chaffer Christine

The plastic cancer cell model establishes that genetically identical cancer cells undergo bi-directional conversions between the highly aggressive tumour-initiating (TIC) state and the non-TIC cell state. We have identified subpopulations of breast cancer cells that readily switch from the non-TIC to TIC state, through activation of the EMT transcription factor ZEB-1. We have shown that non-TICs of basal BrCa are uniquely endowed with this plastic phenotype due to the cell&#14...