Searchable abstracts of presentations at key conferences in oncology

oa0001p028 | (1) | PacRim7

Immune signalling is a key driver of breast density and breast cancer risk

Archer Maddison , Sun Xuan , Glynn Danielle J , Hodson Leigh J , Huo Cecilia , Britt Kara , Thompson Erik , Woolford Lucy , Evdokiou Andreas , W Pollard Jeffrey , Robertson Sarah A , Ingman Wendy V

High breast density is an independent risk factor for breast cancer. There is exciting potential for breast density to become a widespread health assessment tool, used to identify the women most at risk of breast cancer in order to intervene early and reduce that risk. However, a better understanding of causal biological mechanisms that lead to high breast density is required in order to develop therapeutic approaches. This project aimed to identify and investigate biological ...

oa0001p036 | (1) | PacRim7

Lipid elongation in prostate cancer: an androgen regulated process and a novel therapeutic target

Nassar Zeyad D , Centenera Margaret M , Machiels Jelle , Zinonos Irene , Hanson Adrienne , Bloch Katarzyna , Mah Chui Yan , Ryan Natalie K , Williams Elizabeth D , Evdokiou Andreas , Tilley Wayne D , Selth Luke A , Butler Lisa M , Swinnen Johannes V

Objective: Although initially effective, androgen deprivation therapy fails to achieve an enduring remission in patients with advanced prostate cancer (PCa) and the cells maintain active androgen receptor (AR) signalling. Hence, a detailed understanding of the AR-driven downstream processes that are required for tumour cell growth and survival, such as lipid metabolism, is essential to reveal new therapeutic targets. In this study, we aimed to evaluate the effect of androgens ...