Searchable abstracts of presentations at key conferences in oncology

oa0001p046 | (1) | PacRim7

A miR-194-regulated transcriptional network is associated with progression to androgen receptor-independent prostate cancer

Fernandes Rayzel C , Dredge Kate , Bert Andrew G , Toubia John , Pillman Katherine A , Gregory Philip A , Hickey Theresa E , Tilley Wayne D , Goodall Gregory J , Selth Luke A

MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression programs and have a critical role in both normal biology and disease. We previously identified microRNA-194 (miR-194) as an important driver of prostate cancer metastasis, although the molecular mechanisms by which it mediates these effects are not well understood. This study aimed to identify target genes and pathways that are responsible for miR-194’s pro-metastatic activity. By integrating tran...