Searchable abstracts of presentations at key conferences in oncology

oa0001p030 | (1) | PacRim7

Androgen receptor binding sites are highly mutated in prostate cancer

Morova Tunc , Gonen Mehmet , Dalal Kush , Gursoy Attila , Keskin Ozlem , Lack Nathan A

Androgen receptor (AR) signalling is essential to nearly all prostate cancer cells. Any alterations to AR-mediated transcription can have a profound effect on prostate carcinogenesis and tumour growth. While the AR protein has been extensively studied, little is know about mutations to the non-coding regions where AR binds to DNA. Using clinical whole genome sequencing, we demonstrate that AR binding sites have a dramatically increased rate of mutations that is greater than an...