Searchable abstracts of presentations at key conferences in oncology

oa0001p048 | (1) | PacRim7

Exploring the clinical significance of interactions between oestrogen and progesterone receptors in breast and endometrioid adenocarcinomas by proximity ligation assay

Snell Cameron E , Smith Deborah , Gough Madeline , Liu Cheng , Middleton Kathryn , Pyke Christopher , Shannon Catherine , Woodward Natasha , Hickey Theresa E , Armes Jane E , Tilley Wayne D

Recent pre-clinical studies indicate that activated progesterone receptor (PR) (particularly the PR-B isoform) binds to oestrogen receptor-α (ER) and reprograms transcription toward better breast cancer outcomes. We investigated whether ER and PR interactions were present in breast and endometrial tumours and associated with clinical parameters including response to endocrine treatments. We developed a proximity ligation assay to detect ER and PR interactions in formalin-...