Searchable abstracts of presentations at key conferences in oncology

oa0001p003 | (1) | PacRim7

Using coordination chemistry and nanotechnology to develop a brand new class of therapeutics

Bally Marcel B , Abrams Michael , Redelmier Tom R , Gilabert-Oriol Roger , Heroux Devon , Chen Kent , Leung Ada WY

We have recently discovered that metals which coordinate with selected compounds can be prepared inside liposomes. This technology, which we refer to as Metaplex¬ô technology, is enabling development of a brand new class of therapeutics. Previously the development of metal drug complexes (CDCs) has been hindered because of their very poor aqueous solubility. As an example, diethyldithiocarbamate (DDC) is the primary metabolite of disulfiram, an approved drug for the treatm...