Searchable abstracts of presentations at key conferences in oncology

oa0001p051 | (1) | PacRim7

Targeting HP1-alpha for prevention and treatment of neuroendocrine prostate cancer

Ci Xinpei , Lin Dong , Collins Colin , Lallous Nada , Hsing Michael , Cherkasov Art , Wang Yuzhuo

NEPC is a lethal subtype of PCa frequently arising from adenocarcinoma via NE transdifferentiation following ADT. In AACR-PCF West Dream Team series of sequential biopsies of over 300 CRPC biopsies, NEPC was discovered in 17% of cases, making neuroendocrine transdifferentiation one of the most common mechanisms underlying ADT resistance. However, a mechanistic understanding of both NEPC development and its aggressiveness remain elusive. Research in this field has been hampered...