Searchable abstracts of presentations at key conferences in oncology

oa0001p001 | (1) | PacRim7

S phase dysregulation occurs following resistance to CDK4/6 inhibition ER+ breast cancer

Alexandrou Sarah , Milioli Heloisa Helena , Portman Neil , Lee Christine , Fernandez Kristine , Blake David , Lim Elgene , Caldon C Elizabeth

Endocrine resistant estrogen receptor positive (ER+) breast cancers are dependent upon cyclin-dependent kinases (CDK) 4/6 for proliferation, making them highly suitable for CDK4/6 inhibitor treatment. Despite initial efficacy, acquired resistance to CDK4/6 inhibitors is emerging and is now a major consideration in pre-clinical and clinical drug development. Current models of CDK4/6 inhibitor resistance do not mimic the clinical scenario where CDK4/6 inhibition will occur in th...

oa0001p008 | (1) | PacRim7

Mechanisms underlying uncontrolled genome doubling in breast cancer

Lee Christine S , Rogers Samuel , Fernandez Kristine , Alexandrou Sarah , Deng Niantao , Sergio C Marcelo , Kulkarni Abhijit , Gugasyan Lucy , Musgrove Elizabeth A , Deans Andrew J , Burgess Andrew , Caldon C Elizabeth

Uncontrolled genome doubling is an underlying cause of cancer cell aneuploidy and genomic instability, but relatively few drivers have been identified for this process. Cyclin E1 and cyclin E2 are cell cycle regulators whose dysregulation in oncogenesis promotes both increased proliferation and genomic instability. Due to their roles in normal physiological endoreduplication of the genome for specialised cell types, we hypothesised that cyclin E1 and cyclin E2 may be drivers o...