Searchable abstracts of presentations at key conferences in oncology

oa0001p002 | (1) | PacRim7

BMP4 is a bonafide breast cancer metastasis suppressor

Eckhardt BL , Redfern A , Sloan EK , Cao Y , Parker BS , Ueno N , Anderson RL

Metastasis is the major cause of death in breast cancer patients, largely due to the poor efficacy of existing therapies. Here we report that bone morphogenetic protein-4 (BMP4) blocks metastasis in animal models of breast cancer and predicts improved survival in patients. In preclinical models of spontaneous metastasis, we demonstrate that BMP4 acts as an autocrine mediator to modulate a range of known metastasis regulating genes, including SMAD7, via activation of c...