Searchable abstracts of presentations at key conferences in oncology

oa0001p015 | (1) | PacRim7

Combinatorial co-targeting by miRNAs: a subtle but strong regulator of epithelia-mesenchymal transitions

Cursons Joseph , Pillman Katherine A , Scheer Kaitlin G , Gregory Philip A , Foroutan Momeneh , Hediyeh-Zadeh Soroor , Toubia John , Crampin Edmund J , Goodall Gregory J , Bracken Cameron P , Davis Melissa J

Epithelial-mesenchymal transition (EMT) and the reverse mesenchymal-epithelial transition (MET) are normal biological processes, however they are also thought to play a critical role in the progression and metastasis of cancers, including breast cancer. Cancer cells reactivate the gene expression programs of EMT and MET through a wide range of mechanisms, and better understanding of these regulatory processes will lead to the identification of therapeutically actionable target...

oa0001p046 | (1) | PacRim7

A miR-194-regulated transcriptional network is associated with progression to androgen receptor-independent prostate cancer

Fernandes Rayzel C , Dredge Kate , Bert Andrew G , Toubia John , Pillman Katherine A , Gregory Philip A , Hickey Theresa E , Tilley Wayne D , Goodall Gregory J , Selth Luke A

MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression programs and have a critical role in both normal biology and disease. We previously identified microRNA-194 (miR-194) as an important driver of prostate cancer metastasis, although the molecular mechanisms by which it mediates these effects are not well understood. This study aimed to identify target genes and pathways that are responsible for miR-194’s pro-metastatic activity. By integrating tran...

oa0001p025 | (1) | PacRim7

Estrogen receptor regulated miR-342 suppresses a pro-metastatic gene network

Lumb Rachael , Arnet Victoria K , Johnstone Cameron N , Pillman Katherine A , Toubia John , Hackett-Jones Emily , Phillips Caroline A , Pinweha Pannapa , Roslan Suraya , Li Xiaochun , Beilharz Traude , Khew-Goodall Yeesim , Goodall Gregory J , Anderson Robin L , Gregory Philip A

Breast cancer is the most frequently diagnosed cancer in women and the second leading cause of female cancer related death. Despite significant advances in early detection, surgery and therapy, treatment remains a challenge if metastatic disease develops. Metastasis occurs with high frequency in triple negative (ER/PR/HER2 negative, TNBC) breast cancers, which are a heterogeneous group of cancers with poor clinical outcome. We used an integrated approach to identify miRNAs tha...