Searchable abstracts of presentations at key conferences in oncology

oa0001p044 | (1) | PacRim7

Epithelial mesenchymal transition, stromal density, and chemo-resistance in breast cancer (BrCa)

Redfern Andrew , Agarwal Veenoo , Spalding Lisa , Blick Tony , Dobrovic Alexander , Thompson Erik W

Introduction: The process of Epithelial Mesenchymal Transition (EMT) involves the transition of cells from a differentiated epithelial phenotype to a less differentiated mesenchymal phenotype. Mammographic breast density (MBD) refers to the proportion of high opacity area on a mammogram. EMT may be triggered in cancer cells by a range of therapies including cytotoxic chemotherapy, with cell line and animal suggesting chemoresistance may result. High MBD in patients being treat...