Searchable abstracts of presentations at key conferences in oncology

oa0001p044 | (1) | PacRim7

Epithelial mesenchymal transition, stromal density, and chemo-resistance in breast cancer (BrCa)

Redfern Andrew , Agarwal Veenoo , Spalding Lisa , Blick Tony , Dobrovic Alexander , Thompson Erik W

Introduction: The process of Epithelial Mesenchymal Transition (EMT) involves the transition of cells from a differentiated epithelial phenotype to a less differentiated mesenchymal phenotype. Mammographic breast density (MBD) refers to the proportion of high opacity area on a mammogram. EMT may be triggered in cancer cells by a range of therapies including cytotoxic chemotherapy, with cell line and animal suggesting chemoresistance may result. High MBD in patients being treat...

oa0001p028 | (1) | PacRim7

Immune signalling is a key driver of breast density and breast cancer risk

Archer Maddison , Sun Xuan , Glynn Danielle J , Hodson Leigh J , Huo Cecilia , Britt Kara , Thompson Erik , Woolford Lucy , Evdokiou Andreas , W Pollard Jeffrey , Robertson Sarah A , Ingman Wendy V

High breast density is an independent risk factor for breast cancer. There is exciting potential for breast density to become a widespread health assessment tool, used to identify the women most at risk of breast cancer in order to intervene early and reduce that risk. However, a better understanding of causal biological mechanisms that lead to high breast density is required in order to develop therapeutic approaches. This project aimed to identify and investigate biological ...