Searchable abstracts of presentations at key conferences in oncology

oa0001p026 | (1) | PacRim7

A molecular portrait of epithelial-mesenchymal plasticity in prostate cancer progression

Stylianou N , Lehman ML , Wang C , Fard AT , Rockstroh A , Fazli L , Jovanovic L , Ward M , Sadowski MC , Kashyap AS , Buttyan R , Gleave ME , Westbrook TF , Williams ED , Gunter JH , Nelson CC , Hollier BG

The propensity of cancer cells to transition between epithelial and mesenchymal phenotypic states via the epithelial-mesenchymal transition (EMT) program can regulate metastatic processes, cancer progression, and treatment resistance. Transcriptional investigations using reversible models of EMT, revealed the mesenchymal-to-epithelial reverting transition (MErT) to be enriched in clinical samples of metastatic castrate resistant prostate cancer (mCRPC). From this enrichment, a...