Searchable abstracts of presentations at key conferences in oncology

oa0001p010 | (1) | PacRim7

Epi-transcriptomic alterations in ER-positive breast cancer

Charmsaz Sara , Cocchiglia Sinead , Doherty Ben , Varešlija Damir , Hill Arnold D , Young Leonie S

Endocrine therapy including tamoxifen and aromatase inhibitors (AIs) are standard therapy for ER- positive breast cancer and despite its success a significant number of patients develop resistance to treatment. Transcriptional and epigenetic re-programing including DNA and RNA methylation develops with high frequency in response to therapy. Global DNA and RNA multi-omic studies have been utilized to understand the altered transcriptome of endocrine resistant breast cancer cell...