Searchable abstracts of presentations at key conferences in oncology

oa0001p022 | (1) | PacRim7

Characterisation of developmental pathways that drive metastatic progression of breast cancer at single cell resolution

Valdes-Mora Fatima , Salomon Robert , Gloss Brian , Law Andrew MK , Murphy Kendelle , Roden Daniel L , Castillo Lesley , Colino-Sanguino Yolanda , Farbehi Nona , Conway James , Timpson Paul , Ormandy Christopher J , Gallego-Ortega David

Tumour cell heterogeneity constitutes a challenge for cancer treatment and deeply impact the outcome of patients. A simultaneous overview of cancer cells and associated stromal cells is critical for the design of improved therapeutic regimes. Single-cell RNA-seq has emerged as a powerful method to unravel heterogeneity of complex biological systems; this has enabled in vivo characterization of cell type compositions through unsupervised sampling and modelling of trans...

oa0001p038 | (1) | PacRim7

Flicking the switch off, targeting MCL-1 in the treatment of breast and prostate cancer

Castillo L , George S , Lin H-M , Yeung N , Mawson A , Young AI , Law AM , Hastings J , Gallego-Ortega D , Deng N , Croucher D , Swarbrick A , Horvath L , Ormandy CJ , Oakes SR

The ability to survive is essential for carcinogenesis. We previously showed that in to addition promoting cancer cell survival, Myeloid Cell Leukemia 1 (MCL-1) regulates cancer cell invasion possibly via direct regulation of the cytoskeletal protein Cofilin and via modulation of the output of the SRC family kinase pathway. We also showed that dual inhibition of MCL-1 and SRC family kinases was effective in suppressing metastasis of breast cancer intraductal xenografts made fr...