PacRim7 7th PacRim Meeting Poster Presentations (1) (52 abstracts)
The ability to survive is essential for carcinogenesis. We previously showed that in to addition promoting cancer cell survival, Myeloid Cell Leukemia 1 (MCL-1) regulates cancer cell invasion possibly via direct regulation of the cytoskeletal protein Cofilin and via modulation of the output of the SRC family kinase pathway. We also showed that dual inhibition of MCL-1 and SRC family kinases was effective in suppressing metastasis of breast cancer intraductal xenografts made from immortalized triple negative breast cancer cells. We are now exploring the potential of targeting MCL-1 alone or in combination with dasatinib and taxane-based cytotoxic therapy in clinically relevant models of metastatic breast and prostate cancer. Here we will report the findings from this study and the progress of a systems biology approach to predicting response.
17 Mar 2019 - 20 Mar 2019