Searchable abstracts of presentations at key conferences in oncology

oa0001p013 | (1) | PacRim7

Single cell transcriptome analysis reveals human prostate cancer cells upregulate retinoic acid signalling in response to androgen withdrawal

Clark Ashlee K , Nim Hieu , Lister Natalie , Lawrence Mitchell G , Keerthikumar Shivakumar , Goode David L , MURAL , Wang Hong , Papargiris Melissa , Ryan Andrew , Azad Arun , Frydenberg Mark , Risbridger Gail P , Taylor Renea A

A current challenge in cancer therapeutics is incomplete response to treatment and emergence of therapy-resistant disease. Androgen deprivation therapy (ADT), the standard treatment for advanced prostate cancer, and effectively reduces the tumour burden in most patients. Yet, residual tumour cells that withstand ADT eventually develop lethal castration-resistance. Eliminating these castrate-tolerant cells, by combining ADT with other treatments, might delay or even prevent cas...